Conformation of Polypyrimidine Tract Binding Protein in Solution

Polypyrimidine Tract-Binding Protein Is

Exon repression by polypyrimidine tract binding protein.

Polypyrimidine tract binding protein (PTB) is known to silence the splicing of many alternative exons. However, exons repressed by PTB are affected by other RNA regulatory elements and proteins. This makes it difficult to dissect the structure of the pre-mRNP complexes that silence splicing, and to understand the role of PTB in this process. We determined the minimal requirements for PTB-mediat...

Polypyrimidine Tract-Binding Protein Down-Regulates

Exclusion of the -exon by alternative RNA splicing of the fibroblast growth factor receptor 1 (FGFR1) primary transcript leads to the production of FGFR1 . Glial cell transformation is associated with a progressive increase in FGFR1 expression that coincides with a dramatic increase in the expression of the splicing factor polypyrimidine tractbinding protein (PTB). Cell-specific overexpression ...

Polypyrimidine tract binding protein antagonizes exon definition.

Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein.

PTB (polypyrimidine-tract-binding protein) is a ubiquitous RNA-binding protein. It was originally identified as a protein with a role in splicing but it is now known to function in a large number of diverse cellular processes including polyadenylation, mRNA stability and translation initiation. Specificity of PTB function is achieved by a combination of changes in the cellular localization of t...